Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.

In experimental animals, injection of gram-negative endotoxin (LPS) decreases hepatic cytochrome P450-mediated drug metabolism. To evaluate this phenomenon in a human model of gram-negative sepsis, LPS was administered on two consecutive days to healthy male volunteers during which time a cocktail o...

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Bibliografski detalji
Glavni autori: Shedlofsky, S I, Israel, B C, McClain, C J, Hill, D B, Blouin, R A
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC330046/
https://ncbi.nlm.nih.gov/pubmed/7989576
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