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Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women

Aims In men, the inflammatory response to intravenous endotoxin depresses apparent oral clearances of antipyrine, hexobarbitone, and theophylline. The aim of this study was to investigate whether there might be gender differences in the regulation of hepatic cytochromes P450. Methods Experiments wer...

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Autori principali: Shedlofsky, S. I., Israel, B. C., Tosheva, R., Blouin, R. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley-Blackwell 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042794/
https://ncbi.nlm.nih.gov/pubmed/9205823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.00603.x
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