The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites.

We designed the N-methylanthranilic-desferrioxamine (MA-DFO) as a fluorescent iron (III) chelator with improved membrane permeation properties. Upon binding of iron (III), MA-DFO fluorescence is quenched, thus allowing traceability of drug-iron (III) interactions. MA-DFO is well tolerated by mammali...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Loyevsky, M, Lytton, S D, Mester, B, Libman, J, Shanzer, A, Cabantchik, Z I
Format: Artigo
Langue:Inglês
Publié: 1993
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC330017/
https://ncbi.nlm.nih.gov/pubmed/8423220
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