The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites.

We designed the N-methylanthranilic-desferrioxamine (MA-DFO) as a fluorescent iron (III) chelator with improved membrane permeation properties. Upon binding of iron (III), MA-DFO fluorescence is quenched, thus allowing traceability of drug-iron (III) interactions. MA-DFO is well tolerated by mammali...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Loyevsky, M, Lytton, S D, Mester, B, Libman, J, Shanzer, A, Cabantchik, Z I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8423220/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116174
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