The antimalarial action of desferal involves a direct access route to erythrocytic (Plasmodium falciparum) parasites.
We designed the N-methylanthranilic-desferrioxamine (MA-DFO) as a fluorescent iron (III) chelator with improved membrane permeation properties. Upon binding of iron (III), MA-DFO fluorescence is quenched, thus allowing traceability of drug-iron (III) interactions. MA-DFO is well tolerated by mammali...
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| Udgivet i: | J Clin Invest |
|---|---|
| Principais autores: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
1993
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8423220/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116174 |
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