Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly

Translation initiation factor eIF3 acts as the key orchestrator of the canonical initiation pathway in eukaryotes, yet its structure is greatly unexplored. We report the 2.2 Å resolution crystal structure of the complex between the yeast seven-bladed β-propeller eIF3i/TIF34 and a C-terminal α-helix...

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Hlavní autoři: Herrmannová, Anna, Daujotytė, Dalia, Yang, Ji-Chun, Cuchalová, Lucie, Gorrec, Fabrice, Wagner, Susan, Dányi, István, Lukavsky, Peter J., Shivaya Valášek, Leoš
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3300007/
https://ncbi.nlm.nih.gov/pubmed/22090426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr765
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