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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as A Protein Kinase

Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate with transferring a phosphate from PEP to ADP. We report here that PKM2 localizes to the cell nucleus. The levels of nuclear PKM2 correlate with cell proliferation. PKM2 activates...

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Detalhes bibliográficos
Main Authors: Gao, Xueliang, Wang, Haizhen, Jenny, J. Yang, Liu, Xiaowei, Liu, Zhi-Ren
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299833/
https://ncbi.nlm.nih.gov/pubmed/22306293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.01.001
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