Pilot Study of the Association of the DDAH2 −449G Polymorphism with Asymmetric Dimethylarginine and Hemodynamic Shock in Pediatric Sepsis

BACKGROUND: Genetic variability in the regulation of the nitric oxide (NO) pathway may influence hemodynamic changes in pediatric sepsis. We sought to determine whether functional polymorphisms in DDAH2, which metabolizes the NO synthase inhibitor asymmetric dimethylarginine (ADMA), are associated w...

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Autores principales: Weiss, Scott L., Yu, Min, Jennings, Lawrence, Haymond, Shannon, Zhang, Gang, Wainwright, Mark S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299781/
https://ncbi.nlm.nih.gov/pubmed/22428028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033355
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