Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria.

The bactericidal/permeability-increasing protein (BPI) of neutrophils and BPI fragments neutralize the effects of isolated Gram-negative bacterial lipopolysaccharides both in vitro and in vivo. Since endotoxin most commonly enters the host as constituents of invading Gram-negative bacteria, we raise...

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Pubblicato in:	J Clin Invest
Autori principali:	Weiss, J, Elsbach, P, Shu, C, Castillo, J, Grinna, L, Horwitz, A, Theofan, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1522221/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115930
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