Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt pathway plays a fundamental role in cell proliferation and survival in human tumorigenesis, including gastric cancer. PIK3CA mutations and amplification are two major causes of overactivation of this pathway in human cancers. However, until this w...

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Autors principals: Shi, Jing, Yao, Demao, Liu, Wei, Wang, Na, Lv, Hongjun, Zhang, Guanjun, Ji, Meiju, Xu, Li, He, Nongyue, Shi, Bingyin, Hou, Peng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299648/
https://ncbi.nlm.nih.gov/pubmed/22292935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-50
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