Fabrication of Carvedilol Nanosuspensions Through the Anti-Solvent Precipitation–Ultrasonication Method for the Improvement of Dissolution Rate and Oral Bioavailability

The present study aims to prepare carvedilol (CAR) nanosuspensions using the anti-solvent precipitation–ultrasonication technique to improve its dissolution rate and oral bioavailability. Alpha-tocopherol succinate (VES) was first used as a co-stabilizer to enhance the stability of the nanosuspensio...

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Bibliographic Details
Main Authors: Liu, Dandan, Xu, Heming, Tian, Baocheng, Yuan, Kun, Pan, Hao, Ma, Shilin, Yang, Xinggang, Pan, Weisan
Format: Artigo
Language:Inglês
Published: Springer US 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299468/
https://ncbi.nlm.nih.gov/pubmed/22246736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-011-9750-7
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