Adalimumab specifically induces CD3(+) CD4(+) CD25(high) Foxp3(+) CD127(−) T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis: a non-randomized pilot intervention study

AIM: To explore immunoregulatory and anti-inflammatory pathways specifically targeted by a subcutaneous anti-TNFαdrug—adalimumab—which might be relevant for controlling refractory uveitis. DESIGN: Non-randomized pilot intervention study on the effects of adalimumab on Treg populations and plasma VEG...

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Detalhes bibliográficos
Main Authors: Calleja, S, Cordero-Coma, M, Rodriguez, E, Llorente, M, Franco, M, Ruiz de Morales, J G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Laboratory Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298996/
https://ncbi.nlm.nih.gov/pubmed/22222264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/eye.2011.320
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