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Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training

The GDI1 gene, responsible in human for X-linked non-specific mental retardation, encodes αGDI, a regulatory protein common to all GTPases of the Rab family. Its alteration, leading to membrane accumulation of different Rab GTPases, may affect multiple steps in neuronal intracellular traffic. Using...

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Detalhes bibliográficos
Main Authors: Bianchi, Veronica, Farisello, Pasqualina, Baldelli, Pietro, Meskenaite, Virginia, Milanese, Marco, Vecellio, Matteo, Mühlemann, Sven, Lipp, Hans Peter, Bonanno, Giambattista, Benfenati, Fabio, Toniolo, Daniela, D'Adamo, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298866/
https://ncbi.nlm.nih.gov/pubmed/18829665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn321
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