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(R)-Profens Are Substrate-Selective Inhibitors of Endocannabinoid Oxygenation by COX-2

Cyclooxygenase-2 (COX-2) catalyzes the oxygenation of arachidonic acid and the endocannabinoids, 2-arachidonoylglycerol and arachidonoylethanolamide. Evaluation of a series of COX-2 inhibitors revealed that many weak, competitive inhibitors of arachidonic acid oxygenation are potent inhibitors of en...

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Bibliografiske detaljer
Main Authors: Duggan, Kelsey C., Hermanson, Daniel J., Musee, Joel, Prusakiewicz, Jeffery J., Scheib, Jami L., Carter, Bruce D., Banerjee, Surajit, Oates, J.A., Marnett, Lawrence J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298755/
https://ncbi.nlm.nih.gov/pubmed/22053353
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