Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

Augmentation of endogenous cannabinoid (eCB) signaling represents an emerging approach to the treatment of affective disorders. Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid to form prostaglandins, but also inactivates eCBs in vitro. However, the viability of COX-2 as a therapeutic target for...

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Bibliografiske detaljer
Main Authors: Hermanson, Daniel J., Hartley, Nolan D., Gamble-George, Joyonna, Brown, Naoko, Shonesy, Brian C., Kingsley, Phillip J., Colbran, Roger J., Reese, Jeffrey, Marnett, Lawrence J., Patel, Sachin
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788575/
https://ncbi.nlm.nih.gov/pubmed/23912944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3480
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