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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
Augmentation of endogenous cannabinoid (eCB) signaling represents an emerging approach to the treatment of affective disorders. Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid to form prostaglandins, but also inactivates eCBs in vitro. However, the viability of COX-2 as a therapeutic target for...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788575/ https://ncbi.nlm.nih.gov/pubmed/23912944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3480 |
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