Tumor necrosis factor downregulates granulocyte-colony-stimulating factor receptor expression on human acute myeloid leukemia cells and granulocytes.

Tumor necrosis factor (TNF) inhibits granulocyte-colony-stimulating factor (G-CSF)-induced human acute myeloid leukemia (AML) growth in vitro. Incubation of blasts from three patients with AML in serum-free medium with TNF (10(3) U/ml), and subsequent binding studies using 125I-G-CSF reveal that TNF...

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Pubblicato in:	J Clin Invest
Autori principali:	Elbaz, O, Budel, L M, Hoogerbrugge, H, Touw, I P, Delwel, R, Mahmoud, L A, Löwenberg, B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329871/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1705566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115087
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