Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells

BACKGROUND: Luteolin is a 3',4',5,7-tetrahydroxyflavone found in various fruits and vegetables. We have shown previously that luteolin reduces HT-29 cell growth by inducing apoptosis and cell cycle arrest. The objective of this study was to examine whether luteolin downregulates the insuli...

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Bibliographic Details
Main Authors: Lim, Do Young, Cho, Han Jin, Kim, Jongdai, Nho, Chu Won, Lee, Ki Won, Park, Jung Han Yoon
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298530/
https://ncbi.nlm.nih.gov/pubmed/22269172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-12-9
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