Effects of partner proteins on BCA2 RING ligase activity

BACKGROUND: BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2....

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Bibliographic Details
Main Authors: Bacopulos, Stephanie, Amemiya, Yutaka, Yang, Wenyi, Zubovits, Judit, Burger, Angelika, Yaffe, Martin, Seth, Arun K
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298473/
https://ncbi.nlm.nih.gov/pubmed/22315970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-63
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