Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis

Many pro-apoptotic signals trigger mitochondrial cytochrome c release, leading to caspase activation and ultimate cellular breakdown. Cell survival pathways, including the mitogen-activated protein kinase (MAPK) cascade, promote cell viability by impeding mitochondrial cytochrome c release and by in...

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Autores principales: Kim, Jiyeon, Parrish, Amanda B, Kurokawa, Manabu, Matsuura, Kenkyo, Freel, Christopher D, Andersen, Joshua L, Johnson, Carrie E, Kornbluth, Sally
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297998/
https://ncbi.nlm.nih.gov/pubmed/22246185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.491
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