Substrate-Dependent Control of ERK Phosphorylation Can Lead to Oscillations

The extracellular signal-regulated kinase (ERK) controls cellular processes by phosphorylating multiple substrates. The ERK protein can use the same domains to interact with phosphatases, which dephosphorylate and deactivate ERK, and with substrates, which connect ERK to its downstream effects. As a...

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Bibliographic Details
Main Authors: Liu, Ping, Kevrekidis, Ioannis G., Shvartsman, Stanislav Y.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2011
Subjects:
Biological Systems and Multicellular Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297790/
https://ncbi.nlm.nih.gov/pubmed/22261044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.025
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