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The 5′ Flanking Region and Intron1 of the Bovine Prion Protein Gene (PRNP) Are Responsible for Negative Feedback Regulation of the Prion Protein

Transcription factors regulate gene expression by controlling the transcription rate. Some genes can repress their own expression to prevent over production of the corresponding protein, although the mechanism and significance of this negative feedback regulation remains unclear. In the present stud...

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Autors principals: Xue, Guangai, Aida, Yoko, Onodera, Takashi, Sakudo, Akikazu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296761/
https://ncbi.nlm.nih.gov/pubmed/22412936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032870
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