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Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

In response to a meal, Glucose-dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) are released from gut endocrine cells into the circulation and interact with their cognate G-protein coupled receptors (GPCRs). Receptor activation results in tissue-selective pleiotropic re...

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Detalhes bibliográficos
Main Authors: Whitaker, Gina M., Lynn, Francis C., McIntosh, Christopher H. S., Accili, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296735/
https://ncbi.nlm.nih.gov/pubmed/22412906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032675
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