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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

Recent human genetics studies have revealed that common variants of the TCF7L2 (T-cell factor 7-like 2, formerly known as TCF4) gene are strongly associated with type 2 diabetes mellitus (T2DM). We have shown that TCF7L2 expression in the β-cells is correlated with function and survival of the insul...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Shu, Luan, Matveyenko, Aleksey V., Kerr-Conte, Julie, Cho, Jae-Hyoung, McIntosh, Christopher H.S., Maedler, Kathrin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722186/
https://ncbi.nlm.nih.gov/pubmed/19386626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp178
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