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Extremely Long-lived Nuclear Pore Proteins in the Rat Brain()

To combat the functional decline of the proteome, cells use the process of protein turnover to replace potentially impaired polypeptides with new functional copies. Here we found that extremely long-lived proteins (ELLPs) did not turn over in post-mitotic cells of the rat central nervous system. The...

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Autori principali: Savas, Jeffrey N., Toyama, Brandon H., Xu, Tao, Yates, John R., Hetzer, Martin W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296478/
https://ncbi.nlm.nih.gov/pubmed/22300851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1217421
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