Destruction Complex Function in the Wnt Signaling Pathway of Drosophila Requires Multiple Interactions Between Adenomatous Polyposis Coli 2 and Armadillo

The tumor suppressor Adenomatous polyposis coli (APC) negatively regulates Wnt signaling through its activity in the destruction complex. APC binds directly to the main effector of the pathway, β-catenin (βcat, Drosophila Armadillo), and helps to target it for degradation. In vitro studies demonstra...

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Detalhes bibliográficos
Main Authors: Kunttas-Tatli, Ezgi, Zhou, Meng-Ning, Zimmerman, Sandra, Molinar, Olivia, Zhouzheng, Fangyuan, Carter, Krista, Kapur, Megha, Cheatle, Alys, Decal, Richard, McCartney, Brooke M.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2012
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296242/
https://ncbi.nlm.nih.gov/pubmed/22174073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.133280
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