COMP-Angiopoietin-1 Recovers Molecular Biomarkers of Neuropathy and Improves Vascularisation in Sciatic Nerve of ob/ob Mice

BACKGROUND: Leptin-deficient ob/ob mice are a model of type 2 diabetes induced peripheral neuropathy. Ob/ob mice exhibit obesity, insulin resistance, hyperglycaemia, and alterations of peripheral nerve fibres and endoneural microvessels. Here we test the hypothesis that cartilage oligomeric matrix p...

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Autors principals: Kosacka, Joanna, Nowicki, Marcin, Klöting, Nora, Kern, Matthias, Stumvoll, Michael, Bechmann, Ingo, Serke, Heike, Blüher, Matthias
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295786/
https://ncbi.nlm.nih.gov/pubmed/22412941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032881
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