Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation

Smooth muscle myosin and heavy meromyosin (smHMM) are activated by regulatory light chain (RLC) phosphorylation but the mechanism remains unclear. Dephosphorylated, inactive smHMM assumes a closed conformation with asymmetric intramolecular head-head interactions between motor domains. The “free hea...

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Detalhes bibliográficos
Main Authors: Baumann, Bruce A. J., Taylor, Dianne W., Huang, Zhong, Tama, Florence, Fagnant, Patricia M., Trybus, Kathleen M., Taylor, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295741/
https://ncbi.nlm.nih.gov/pubmed/22079364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.047
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