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PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations
PURPOSE: Mutations of the PIK3CA gene may predict response to phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) inhibitors. Concomitant mutations in the mitogen-activated protein kinase (MAPK) pathway may mediate resistance. PATIENTS AND METHODS: Tumors from patients with...
שמור ב:
Main Authors: | , , , , , , , , , , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
American Society of Clinical Oncology
2012
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3295566/ https://ncbi.nlm.nih.gov/pubmed/22271473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.36.1196 |
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