Desensitization of adenosine receptor-mediated inhibition of lipolysis. The mechanism involves the development of enhanced cyclic adenosine monophosphate accumulation in tolerant adipocytes.

Adipocytes contain adenosine receptors, termed A1 receptors, which inhibit lipolysis by decreasing adenylate cyclase activity. The inhibition of lipolysis by adenosine agonists in vivo acutely suppresses the plasma concentrations of free fatty acids (FFA) and triglycerides. We have found that infusi...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Hoffman, B B, Chang, H, Dall'Aglio, E, Reaven, G M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1986
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329548/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3013937/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112550
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