Desensitization of adenosine receptor-mediated inhibition of lipolysis. The mechanism involves the development of enhanced cyclic adenosine monophosphate accumulation in tolerant adipocytes.

Adipocytes contain adenosine receptors, termed A1 receptors, which inhibit lipolysis by decreasing adenylate cyclase activity. The inhibition of lipolysis by adenosine agonists in vivo acutely suppresses the plasma concentrations of free fatty acids (FFA) and triglycerides. We have found that infusi...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Hoffman, B B, Chang, H, Dall'Aglio, E, Reaven, G M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1986
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329548/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3013937/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112550
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