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Localization of the binding site of tissue-type plasminogen activator to fibrin.
Functionally active A and B chains were separated from a two-chain form of recombinant tissue-type plasminogen activator after mild reduction and alkylation. The A chain was found to be responsible for the binding to lysine-Sepharose or fibrin and the B chain contained the catalytic activity of tiss...
Enregistré dans:
| Publié dans: | J Clin Invest |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
1986
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329545/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3088041/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112546 |
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