Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species

Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis (“sleeping sickness”) across sub-Saharan Africa and is a model system for antigenic variation, surv...

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Hauptverfasser: Jackson, Andrew P., Berry, Andrew, Aslett, Martin, Allison, Harriet C., Burton, Peter, Vavrova-Anderson, Jana, Brown, Robert, Browne, Hilary, Corton, Nicola, Hauser, Heidi, Gamble, John, Gilderthorp, Ruth, Marcello, Lucio, McQuillan, Jacqueline, Otto, Thomas D., Quail, Michael A., Sanders, Mandy J., van Tonder, Andries, Ginger, Michael L., Field, Mark C., Barry, J. David, Hertz-Fowler, Christiane, Berriman, Matthew
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295286/
https://ncbi.nlm.nih.gov/pubmed/22331916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117313109
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