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Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR

Previously we demonstrated that the heat shock transcription factor Hsf1 is indispensable for transformation of mammary epithelial cells by the Her2 oncogene. Since Hsf1 affects oncogene-induced senescence (OIS), these findings suggest that Hsf1 affects tumor initiation when OIS plays a role. Indeed...

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Detalles Bibliográficos
Main Authors: Gabai, Vladimir L., Meng, Le, Kim, Geunwon, Mills, Teresa A., Benjamin, Ivor J., Sherman, Michael Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295200/
https://ncbi.nlm.nih.gov/pubmed/22215620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05921-11
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