Pharmacokinetics of Lamivudine and Lamivudine-Triphosphate after Administration of 300 Milligrams and 150 Milligrams Once Daily to Healthy Volunteers: Results of the ENCORE 2 Study

There is interest in evaluating the efficacy of lower doses of certain antiretrovirals for clinical care. We determined here the bioequivalence of plasma lamivudine (3TC) and intracellular 3TC-triphosphate (3TC-TP) concentrations after the administration of two different doses. ENCORE 2 was a random...

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Autores principales: Else, Laura J., Jackson, Akil, Puls, Rebekah, Hill, Andrew, Fahey, Paul, Lin, Enmoore, Amara, Alieu, Siccardi, Marco, Watson, Victoria, Tjia, John, Emery, Sean, Khoo, Saye, Back, David J., Boffito, Marta
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294959/
https://ncbi.nlm.nih.gov/pubmed/22183172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05599-11
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