Discordant Temporal Evolution of Pfcrt and Pfmdr1 Genotypes and Plasmodium falciparum In Vitro Drug Susceptibility to 4-Aminoquinolines after Drug Policy Change in French Guiana

Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i....

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Autores principales: Legrand, Eric, Yrinesi, Joséphine, Ekala, Marie-Thérèse, Péneau, Julie, Volney, Béatrice, Berger, Franck, Bouchier, Christiane, Bertani, Stéphane, Musset, Lise, Meynard, Jean-Baptiste, Mercereau-Puijalon, Odile
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294927/
https://ncbi.nlm.nih.gov/pubmed/22232280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05280-11
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