Discordant Temporal Evolution of Pfcrt and Pfmdr1 Genotypes and Plasmodium falciparum In Vitro Drug Susceptibility to 4-Aminoquinolines after Drug Policy Change in French Guiana

Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i....

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Detalhes bibliográficos
Main Authors: Legrand, Eric, Yrinesi, Joséphine, Ekala, Marie-Thérèse, Péneau, Julie, Volney, Béatrice, Berger, Franck, Bouchier, Christiane, Bertani, Stéphane, Musset, Lise, Meynard, Jean-Baptiste, Mercereau-Puijalon, Odile
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294927/
https://ncbi.nlm.nih.gov/pubmed/22232280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05280-11
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