Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar

Molecular studies have demonstrated that mutations in the Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) play a major role in chloroquine resistance, while mutations in P. falciparum multidrug resistance gene (Pfmdr-1) act as modulator. In Madagascar, the high rate of chloroqu...

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Hauptverfasser: Andriantsoanirina, Valérie, Ratsimbasoa, Arsène, Bouchier, Christiane, Tichit, Magali, Jahevitra, Martial, Rabearimanana, Stéphane, Raherinjafy, Rogelin, Mercereau-Puijalon, Odile, Durand, Rémy, Ménard, Didier
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954150/
https://ncbi.nlm.nih.gov/pubmed/20967251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013281
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