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Reevaluation of the Critical Concentration for Drug Susceptibility Testing of Mycobacterium tuberculosis against Pyrazinamide Using Wild-Type MIC Distributions and pncA Gene Sequencing

Pyrazinamide (PZA) is a potent first-line agent for the treatment of tuberculosis (TB) with activity also against a significant part of drug-resistant Mycobacterium tuberculosis strains. Since PZA is active only at acid pH, testing for susceptibility to PZA is difficult and insufficiently reproducib...

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Autors principals: Werngren, J., Sturegård, E., Juréen, P., Ängeby, K., Hoffner, S., Schön, T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294906/
https://ncbi.nlm.nih.gov/pubmed/22203587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05894-11
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