Delivery of Large Heterologous Polypeptides across the Cytoplasmic Membrane of Antigen-Presenting Cells by the Bordetella RTX Hemolysin Moiety Lacking the Adenylyl Cyclase Domain

The Bordetella adenylate cyclase toxin-hemolysin (CyaA; also called ACT or AC-Hly) targets CD11b-expressing phagocytes and translocates into their cytosol an adenylyl cyclase (AC) that hijacks cellular signaling by conversion of ATP to cyclic AMP (cAMP). Intriguingly, insertion of large passenger pe...

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Detalhes bibliográficos
Main Authors: Holubova, Jana, Kamanova, Jana, Jelinek, Jiri, Tomala, Jakub, Masin, Jiri, Kosova, Martina, Stanek, Ondrej, Bumba, Ladislav, Michalek, Jaroslav, Kovar, Marek, Sebo, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294662/
https://ncbi.nlm.nih.gov/pubmed/22215742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05711-11
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