Phenotypic Characterization of a copA Mutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress

NGO0579 is annotated copA in the Neisseria gonorrhoeae chromosome, suggesting that it encodes a cation-transporting ATPase specific for copper ions. Compared to wild-type cells, a copA mutant was more sensitive to killing by copper ions but not to other transition metals. The mutant also accumulated...

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Main Authors: Djoko, Karrera Y., Franiek, Jessica A., Edwards, Jennifer L., Falsetta, Megan L., Kidd, Stephen P., Potter, Adam J., Chen, Nathan H., Apicella, Michael A., Jennings, Michael P., McEwan, Alastair G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294635/
https://ncbi.nlm.nih.gov/pubmed/22184419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06163-11
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