Role of Francisella Lipid A Phosphate Modification in Virulence and Long-Term Protective Immune Responses

Lipopolysaccharide (LPS) structural modifications have been shown to specifically affect the pathogenesis of many Gram-negative pathogens. In Francisella, modification of the lipid A component of LPS resulted in a molecule with no to low endotoxic activity. The role of the terminal lipid A phosphate...

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Detalhes bibliográficos
Main Authors: Kanistanon, Duangjit, Powell, Daniel A., Hajjar, Adeline M., Pelletier, Mark R., Cohen, Ilana E., Way, Sing Sing, Skerrett, Shawn J., Wang, Xiaoyuan, Raetz, Christian R. H., Ernst, Robert K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294632/
https://ncbi.nlm.nih.gov/pubmed/22215738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.06109-11
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