Polymerase chain reaction facilitates the cloning, CDR-grafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte integrins.

Two novel approaches of recombinant PCR technology were employed to graft the complementarity determining regions from a murine monoclonal antibody (mAb) onto human antibody frameworks. One approach relied on the availability of cloned human variable region templates, whereas the other strategy was...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Nucleic Acids Res
Hoofdauteurs:	Daugherty, B L, DeMartino, J A, Law, M F, Kawka, D W, Singer, I I, Mark, G E
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Oxford University Press 1991
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC329459/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1674999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.9.2471
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!