SPATIOTEMPORAL INHIBITION OF INNATE IMMUNITY SIGNALING BY THE TBC1D23 RAB-GAP()

We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using Tbc1d23 knockout mice and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a general inhibitor of innate imm...

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Autori principali: De Arras, Lesly, Yang, Ivana V., Lackford, Brad, Riches, David W. H., Prekeris, Rytis, Freedman, Jonathan H., Schwartz, David A., Alper, Scott
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293945/
https://ncbi.nlm.nih.gov/pubmed/22312129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102595
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