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SPATIOTEMPORAL INHIBITION OF INNATE IMMUNITY SIGNALING BY THE TBC1D23 RAB-GAP()

We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using Tbc1d23 knockout mice and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a general inhibitor of innate imm...

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Detalhes bibliográficos
Main Authors: De Arras, Lesly, Yang, Ivana V., Lackford, Brad, Riches, David W. H., Prekeris, Rytis, Freedman, Jonathan H., Schwartz, David A., Alper, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293945/
https://ncbi.nlm.nih.gov/pubmed/22312129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102595
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