A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein–dependent signaling

Platelets are essential for normal hemostasis, but close regulation is required to avoid the destructive effects of either inappropriate platelet activation or excessive responses to injury(.) Here, we describe a novel complex comprising the scaffold protein, spinophilin (SPL), and the tyrosine phos...

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Detalhes bibliográficos
Main Authors: Ma, Peisong, Cierniewska, Aleksandra, Signarvic, Rachel, Cieslak, Marcin, Kong, Hong, Sinnamon, Andrew J., Neubig, Richard R., Newman, Debra K., Stalker, Timothy J., Brass, Lawrence F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293648/
https://ncbi.nlm.nih.gov/pubmed/22210881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-387910
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