A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein–dependent signaling

Platelets are essential for normal hemostasis, but close regulation is required to avoid the destructive effects of either inappropriate platelet activation or excessive responses to injury(.) Here, we describe a novel complex comprising the scaffold protein, spinophilin (SPL), and the tyrosine phos...

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Autors principals: Ma, Peisong, Cierniewska, Aleksandra, Signarvic, Rachel, Cieslak, Marcin, Kong, Hong, Sinnamon, Andrew J., Neubig, Richard R., Newman, Debra K., Stalker, Timothy J., Brass, Lawrence F.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293648/
https://ncbi.nlm.nih.gov/pubmed/22210881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-387910
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