Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor

Cancer regression by gene-modified T cells bearing a chimeric antigen receptor (CAR) exodomain of mouse origin can be limited by the induction of transgene immunogenicity resulting in poor persistence and function in vivo. The development of functionally-active CAR of human origin can address this i...

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Bibliographische Detailangaben
Hauptverfasser: Lanitis, Evripidis, Poussin, Mathilde, Hagemann, Ian S, Coukos, George, Sandaltzopoulos, Raphael, Scholler, Nathalie, Powell, Daniel J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293635/
https://ncbi.nlm.nih.gov/pubmed/22127019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.256
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