Phase I Trial of “bi-shRNAi(furin)/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer

We performed a phase I trial of FANG vaccine, an autologous tumor-based product incorporating a plasmid encoding granulocyte-macrophage colony-stimulating factor (GMCSF) and a novel bifunctional short hairpin RNAi (bi-shRNAi) targeting furin convertase, thereby downregulating endogenous immunosuppre...

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Autori principali: Senzer, Neil, Barve, Minal, Kuhn, Joseph, Melnyk, Anton, Beitsch, Peter, Lazar, Martin, Lifshitz, Samuel, Magee, Mitchell, Oh, Jonathan, Mill, Susan W, Bedell, Cynthia, Higgs, Candice, Kumar, Padmasini, Yu, Yang, Norvell, Fabienne, Phalon, Connor, Taquet, Nicolas, Rao, Donald D, Wang, Zhaohui, Jay, Chris M, Pappen, Beena O, Wallraven, Gladice, Brunicardi, F Charles, Shanahan, David M, Maples, Phillip B, Nemunaitis, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293620/
https://ncbi.nlm.nih.gov/pubmed/22186789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.269
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