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Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

Short regulatory oligonucleotides (ONs) have a great therapeutic potential for the modulation of gene expression due to their high specificity and low toxicity. The major obstacles for in vivo clinical applications of ONs are the poor permeability of plasma membrane to nucleic acids and the sensitiv...

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Autori principali: Margus, Helerin, Padari, Kärt, Pooga, Margus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293609/
https://ncbi.nlm.nih.gov/pubmed/22233581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.284
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