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Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

Short regulatory oligonucleotides (ONs) have a great therapeutic potential for the modulation of gene expression due to their high specificity and low toxicity. The major obstacles for in vivo clinical applications of ONs are the poor permeability of plasma membrane to nucleic acids and the sensitiv...

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Detalhes bibliográficos
Main Authors: Margus, Helerin, Padari, Kärt, Pooga, Margus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293609/
https://ncbi.nlm.nih.gov/pubmed/22233581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.284
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