Apoptotic DNA Degradation into Oligonucleosomal Fragments, but Not Apoptotic Nuclear Morphology, Relies on a Cytosolic Pool of DFF40/CAD Endonuclease

Apoptotic cell death is characterized by nuclear fragmentation and oligonucleosomal DNA degradation, mediated by the caspase-dependent specific activation of DFF40/CAD endonuclease. Here, we describe how, upon apoptotic stimuli, SK-N-AS human neuroblastoma-derived cells show apoptotic nuclear morpho...

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Autores principales: Iglesias-Guimarais, Victoria, Gil-Guiñon, Estel, Gabernet, Gisela, García-Belinchón, Mercè, Sánchez-Osuna, María, Casanelles, Elisenda, Comella, Joan X., Yuste, Victor J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293563/
https://ncbi.nlm.nih.gov/pubmed/22253444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290718
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