α7 Nicotinic Acetylcholine Receptor Agonism Confers Neuroprotection Through GSK-3β Inhibition in a Mouse Model of Intracerebral Hemorrhage

BACKGROUND AND PURPOSE: Perihematomal edema formation and consequent cell death contribute to the delayed brain injury evoked by intracerebral hemorrhage (ICH). In this study we aimed to evaluate the effect of α7 nicotinic acetylcholine receptor (α7nAChR) stimulation, on behavior, brain edema and ne...

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Auteurs principaux: Krafft, Paul R., Altay, Orhan, Rolland, William B., Duris, Kamil, Lekic, Tim, Tang, Jiping, Zhang, John H.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293395/
https://ncbi.nlm.nih.gov/pubmed/22207510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.111.639989
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