Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8

Cerebral ischemia causes increased transcription of sulfonylurea receptor 1 (SUR1), which forms SUR1-regulated NC(Ca-ATP) channels linked to cerebral edema. We tested the hypothesis that hypoxia is an initial signal that stimulates transcription of Abcc8, the gene encoding SUR1, via activation of hy...

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Detalhes bibliográficos
Main Authors: Woo, Seung Kyoon, Kwon, Min Seong, Geng, Zhihua, Chen, Zheng, Ivanov, Alexander, Bhatta, Sergei, Gerzanich, Volodymyr, Simard, J Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293117/
https://ncbi.nlm.nih.gov/pubmed/22086197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.159
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