IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice

BACKGROUND: Antibodies of the IgG3 subclass have been implicated in the pathogenesis of the spontaneous glomerulonephritis observed in mice of the MRL/MpJ-Tnfrsf6lpr (MRL/lpr) inbred strain which have been widely studied as a model of systemic lupus erythematosus We have produced IgG3-deficient (-/-...

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Main Authors:	Greenspan, Neil S, Lu, Myro A, Shipley, Jacob W, Ding, Xuedong, Li, Qing, Sultana, Dilara, Kollaros, Maria, Schreiber, John R, Fu, Pingfu, Putterman, Chaim, Emancipator, Steven N
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2012
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3293080/ https://ncbi.nlm.nih.gov/pubmed/22248284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-7-3
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IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice

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