Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels

BACKGROUND: Imiquimod (IQ) is known as an agonist of Toll-like receptor 7 (TLR7) and is widely used to treat various infectious skin diseases. However, it causes severe itching sensation as its side effect. The precise mechanism of how IQ causes itching sensation is unknown. A recent report suggeste...

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Detalhes bibliográficos
Main Authors: Lee, Jaekwang, Kim, Taekeun, Hong, Jinpyo, Woo, Junsung, Min, Hyunjung, Hwang, Eunmi, Lee, Sung Joong, Lee, C Justin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292985/
https://ncbi.nlm.nih.gov/pubmed/22233604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-2
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